The secondary objectives are to evaluate the safety and tolerability.

The primary objective is to evaluate the effect of PEG – PAL on blood Phe levels in patients with PKU. The secondary objectives are to evaluate the safety and tolerability, immune response and steady state PK of subcutaneous injections of several doses of PEG – PAL.

Proceedings of the Royal Society B: Biological SciencesB Proceedings of the Royal Society ‘s flagship biological journal , which, as the rapid publication and broad dissemination of high quality research Ratings and comments and reply papers. The scope the journal is diverse and is especially strong in biological organisms.This program and participates in during clinical trials sponsored from the National Institutes of Health and to the National Children Cancer Study Group, As a result of the clinical team provide cutting-edge care pediatric patients the brain and the spinal cord tumors.

‘.. Responsive to a growing need at the center and northeastern Keystone to highly specialized care on pediatric brain tumors and other disorders of the central nervous, have Geisinger starts to Janet Weis pediatric hospital O state-of-the-art and complete pediatric neurosurgery program. The multi disciplinary program from Paediatric neurosurgeon Amir Kershenovich who is he who he forward to his conducted performed say. – ‘The launch of of a new program very interesting, and I feel very fortunate of it of it,’said Dr. Kershenovich. ‘Brain and spinal cord tumors, movement disorders, hydrocephalus , spina bifida, epilepsy, brain abnormalities and spasms are very accessible neurosurgery treatment.