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Variants in this sequence made an appearance with considerably greater frequency in kids suffering from asthma and so are therefore a very clear risk factor. The function of the gene complicated remains completely unknown. ‘We only understand that ORMDL3 is usually expressed on the endoplasmatic reticulum, an organelle. This ORMDL3 expression is prominent in lots of tissues and cells, specifically in immune cells’, says Prof. Bufe. ‘Here we’ve discovered something that is totally unknown, new – this might start a whole new perspective of our knowledge of children’s asthma’, he expectations.